Spray drying method and apparatus

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Inventors

Kantor, Martin L.

Application #

475882

Filed

Jun-7-1995

Published

Sep-16-1997

Current US Class

264/4.1
264/4.3
264/4.33
424/484
424/485
424/486
424/489
424/490
424/491
424/497
424/499

International Classes

A61K 009/16; A61K 009/50

Field of Search

424/484 424/485 424/486 424/489 424/490 424/491 424/497 424/499 264/4.1 264/4.3 264/4.33

Assignee

Emisphere Technologies, Inc. (Hawthorne, NY)

Examiners

Nutter; Nathan M.

Attorney, Agent or Firm

Darby & Darby

US Patent References

Referenced by:

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Other References

Airaudo, C.B. et al. (1987) Journal of Food Science, vol. 52(6), pp. 1750-1752. Andini, S. et al. (1975) Origins of Life, vol. 6, pp. 147-153. Brooke, S. 1 et al. (1977) BioSystems, vol. 9, pp. 1-22. Chen et al. (1975) "Evidence for Hemiacetal Formation", Biochemistry, vol. 18, No. 5, pp. 921-925. Davis et al. (1983) "Leucinal Inhibits . . . ", Pharmacology Biochemistry Behavior, vol. 19, pp. 791-794. Dose, K. (1974) Origins of Life, vol. 5, pp. 239-252. Fasman et al. (1964) Biochemistry, vol. 3, No. 11, pp. 1665-1674. Fox, S.W. et al. (1976) BioSystems, vol. 8, pp. 40-44. Fox, S.W. et al., Molecular Evolution and the Origin of Life, Maxel Decker, New York (1977). Fox, S.W.. (1976) Origins of Life, vol. 7, pp. 49-68. Fox, S.W. (1980) Naturwissenschaften, vol. 67, pp. 378-383. Fox, S.W. et al. (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 281-285. Fox, S.W. et al. (1974) Origins of Life, vol. 5, pp. 227-237. Fox, S.W. (1984) Origins of Life, vol. 14, pp. 485-488. Gol'dovskii, A.M. (1978) Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, vol. 14(6), pp. 437-439. Gurrieri, S. et al,. (1973) Thermochimica Acta, vol. 7, pp. 231-239. Harada, K. et al. (1979) BioSystems, vol. 11, pp. 47-53. Harada et al., (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 274-280. Hare (1970) Etude Cenetique De La Polycondensaaon Thermique D'.sub.X -Amino Acides, vol. 45, pp. 330-339. Heinrich, M.R. et al. (1969) Archives of Biochemistry and Biophysics, vol. 130, pp. 441-448. Heinz, B. et al. (1981) BioSystems, vol. 14, pp. 33-40. Hennon, G. et al. (1975) Biochimie, vol. 57, pp. 1395-1396. Hsu, L.L. et al. (1976) BioSystems, vol. 8, pp. 89-101. Hsu, L.L. et al. (1971) Currents in Modern Biology, vol. 4, pp. 12-25. Ishima, Y. et al. (1981), BioSystems, vol. 14, pp. 243-251. Jackson et al. (1991) "Pharmacological . . . ", J. Pharm. & Exp. Thera., vol. 261, No. 1, pp. 546-552. Kokufuta, E. et al. (1984) BioSystems, vol. 16, pp. 175-181. Jungck, J.R. et al. (1973) Naturwissenschaten, vol. 60, pp. 425-427. Krampitz, G. et al,. (1967) Naturwissenschaften, pp. 516-517. Krampitz, G. et al. (1968) Naturwissenschaften, pp. 345 and 346. Krampitz, G. et al. (1966) Naturwissenschaften, pp. 7 and 8. Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 9-17. Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 1-7. Masinovsky, Z. et al. (1989) BioSystems, vol. 22, pp. 305-310. Martinez Luque-Romero, M. et al. (1986) BioSystems, vol. 19, pp. 267-272. Matsuno, K. (1982) BioSystems, vol. 15, pp. 1-11. Matsuno, K. (1984) BioSystems, vol. 17, pp. 11-14. Matsuno, K. (1981) BioSystems, vol. 14, pp. 163-170. McAlhaney, W.W. et al. (1976) BioSystems, vol. 8, pp. 45-50. Melius, P. et al. (1987) BioSystems, vol. 20, pp. 213-217. Melius, P. et al. (1975) Bioorganic Chemistry, vol. 4, pp. 385-391. Melius, P. (1979) BioSystems, vol. 11, pp. 125-132. Miquel, J. et al. (1971) Currents in Modern Biology, vol. 3, pp. 299-306. Nakashima, T. et al. (1980) J. Mol. Evol., vol. 15, pp. 161-168. Nakashima, T. et al. (1981) BioSystems, vol. 14, pp. 151-161. Novak, V.J.A. (1984) Origins of Life, vol. 14, pp. 513-522. Olafsson, P.G. et al. (1971) Polymer Letters, vol. 9, pp. 521-528. Phillips, R.D. et al. (1974) Int. J. Peptide Protein Res., vol. 6, pp. 309-319. Przybylski, A.T. et al. (1982) Die Naturwissenschaften, vol. 69, pp. 561-563. Przybylski, A.T. et al. (1984) Applied Biochemistry and Biotechnology, vol. 10, pp. 301-307. Przybylski, A.T. (1985) BioSystems, vol. 17, pp. 281-288. Rohlfing, D.L. (1975) Origins of Life, vol. 6, pp. 203-209. Rohlfing, D.L. (1970) Science, vol. 169, pp. 998-1000. Rohlfing, D.L. (1967) Archives of Biochemistry and Biophysics, vol. 118, pp. 468-474. Rohlfing, D.L. et al. Catalytic Activities of Thermal Polyanhydro-.alpha.-Amino Acids, pp. 373-418. Rohlfing, D.L. et al. (1976) BioSystems, vol. 8, pp. 139-145. Ryan, J.W. et al. (1973) BioSystems, vol. 5, pp. 115-118. Saunders, M.A. et al. (1974) BioSystems, vol. 6, pp. 81-92. Snyder, W.D. et al. (1975) BioSystems, vol. 7, pp. 222-229. Sokol, P.K (1974) Journal of the American Oil Chemists' Society, vol. 52, pp. 101-102. Tschager et al. (1988) Milchwirtschaftliche Berichte, vol. 95, pp. 79-83. Vaughan, G. et al. (1987) BioSystems, vol. 20, pp. 219-223. Vol'kenshtein, M.V. (1989) Molekulyarnaya Biologiya, vol. 23(1), pp. 23-37. Waelmeldt, T.V. et al. (1968) Biochim. Biophys. Acta, vol. 160, pp. 239-245. Williams et al. (1991) J. Biol. Chem., vol. 266, No. 8, pp. 5182-5190. Yuki, A. et al. (1969) Biochemical and Biophysical Research Communications, vol. 36(4), pp. 657-663. Zulaski et al. (1983) "New Carboxyalkyl Inhibitors of Brain Enkenphalinase", J. Med. Chem., 26, pp. 60-65. (1985) Chemical Abstracts, vol. No. 105(1), Abstract No. 12027p. (1985) Chemical Abstracts, vol. No. 102(6), Abstract No. 50870d. Chemical Abstract, vol. 80(9) Abst. No. 52392a (1974). Bergeron, Raymond J., et al. (1994) "Macromolecular Self-Assembly of Diketopiperazine Tetrapeptides", Journal of the American Chemical Society, vol. 116, pp. 8479-8484. Bergeron, Raymond J., et al. (1993) "A Comparative Study of the Iron-Clearing Properties of Desferrithiocin Analogues With Desferrioxamine B in a Cebus Monkey Model", Blood, vol. 81, No. 8, pp. 2166-2173. Bergeron, Raymond J., et al. (1992) "A Comparison of the Iron-Clearing Properties of 1,2-Dimethyl-3-Hydroxypyrid-4-One, 1,2-Diethyl-3-Hydroxypyrid-4-One, and Deferoxamine", Blood, vol. 79, No. 7, pp. 1882-1890. Bergeron, Raymond J., et al. (1991) "Evaluation of Desferrithiocin and Its Synthetic Analogs as Orally Effective Iron Chelators", Journal of Medicinal Chemistry, vol. 34, No. 7, pp. 2072-2078. Bergeron, Raymond et al., "A Comparative Evaluation of Iron Clearance Models", Annals New York Academy of Sciences, pp. 378-393 (1990). Andriuoli, G., et al. (1990), Haemostasis 20 (suppl. 1):154-158. Caramazza, I., et al. (1991), Thrombosis Research 62:785-789. Guarini, S., et al. (1983), Experimentia 41:350-352. Guarini, S., et al. (1985), Pharmacological Research Communications 17(8):685-697. Dal Pozzo, A., et al. (1989), Thrombosis Research 56:119-124. Gelb, R., et al (1983), Lite Sciences 33(1):83-85. Watterberg et al. (1988), Pediatric Research, vol. 23, No. 4, part 2, p. 570A, column 1, abstract No. 2209. Bernstein (1985), Chest 87(1):68S-73S. Damage et al. (1988), Diabetes 246-251. 184358, Chemical Abstracts:83 (1975). Amino, Y., et al., Chem. Pharm. Bull. 36(11):4426-4434 (1988). Baughman, R.A. et al., Proc. of the 6th Inter'l. Symp. on Recent Advs. in Drug Delivery Systems, Ctr. for Controlled Chem. Delivery, University of Utah, Feb. 22-25, 1993, Salt Lake City, UT, pp. 179-180 "Method for Assessing The Stability of Proteinold Microspheres". Haas, S. et al., "Assessment Of Stability Of Proteinold Microspheres", Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. X. Ma, et al., Proceed. Intern. Syrup. Control. Rel Bioact. Mater., 20 (1993), Controlled Release Society, Inc. "IN VITRO Mechanistic Investigation of the Proteinold Microsphere Oral Delivery System". Yen, H.-R H., et al., "Adsorption of Sulforhodamine 101 on Proteinold Microspheres" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. Presented at "IBC Rational Drug Design Conference", San Diego, Calif.--Dec. 1994. Bergeron, Raymond J. et al., J. Am. Chem. Soc. 1994, 116,8479-8484 "Macromolecular Self-Assembly of Diketopiperazine Tetrapeptides". Leone-Bay et al., Presented at "Winter Conference on Medicinal and Bioorganic Chemistry" Steamboat Springs, Colorado--Feb. 1995 Microsphere Formation and Drug Delivery in a Series of Derivatized Amino Acids. Santiago et al., Pharm. Res. 11: 1994, pp.8-298 "Oral Delivery of Heparin Microspheres made with Modified Amino Acids". Leone-Bay et al., Pharm. Res. 11: 1994, p.S-121 "Oral Delivery of Heparin using Acylated Amino Acids". Sarubbi et al., Pharm. Res. 1994, p.S-299 "Oral Calcitonin Delivery using the PODDS Technology". Leipold et al., Pharm. Res. 11: 1994, p.S-298 "Oral Delivery of Interferon in Rats and Primates". Santiago et al., Pharm. Res. 11: 1994, p.S-298 "Evaluation in Rats of Vehicles for the Oral Delivery of Low Molecular Weight Heparin". Milstein et al., Symposia Abstracts. AAPS Annual Meeting, San Antonia, TX, Nov. 15-19, 1993. X. Ma et al., PDD 7303 Pharmaceutical Research 9(10):S-244, 1992 (Oct. Supplement). Santiago et al. "Initial Studies In The Assessment of Proteinold Microsphere Activity" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. Santiago et al. "Proteinold Microspheres For The Oral Delivery of Heparin" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc. pp. 514-515. Santiago et al. "Oral Immunization of Rats with Influenza Virus M Protein (M1) Microspheres" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc., p. 116-117. Santiago et al. American Society for Microbiology 92nd General Meeting, Abstract of the General Meeting, p. 159, May 26-30, 1992. Milstein et al. "Preparation And In Vitro Characterization Of Proteinoid Microspheres" Proceed Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc. pp. 516-517. Doris K. Chiappetta, Eastern Analytical Symposium, Nov. 17, 1992 "Solutions for Problems in Bioanalysis". Elizabeth A. Harris. M.S., Eastern Analytical Symposium, Nov. 17, 1992 "Solutions for Problems in Bioanaylsis". AAPS 6th Ann. Meeting and Expo., "Proteinoids--A Novel Drug Delivery System" Nov. 19, 1992, p. 33. Milstein et al., "Efficient Oral Delivery Of Monoclonal Antibodies By Proteinoid Encapsulation" The 1993 Miami Bio/Technology Winter Symposium--Advances in Gene Technology: Protein Engineering and Beyond, Jan. 17-22, 1993. Xinghang Ma, et al. "Stability Study of Drug-loaded Proteinoid Microsphere Formulations during Freeze-drying" Journal of Drug Targeting, 1994, vol. 2, pp. 9-21. Baughman et al., "Screening Candidate Microsphere Formulations By Incubating In Simulated Digestive Fluids" Proc. of the 6th Intern'l. Sympo. on Recent Advances in Drug Delivery Systems, Ctr. for Controlled Chem. Delivery, University of Utah, Feb. 22-25, 1993, pp. 181-182. Robert O. Dillman, M.D., Annals of Internal Medicine 1989:111 pp. 592-600, "Monoclonal Antibodies for Treating Cancer". Brendan D. Curti, Critical Reviews in Oncology/Hematology, 1993: 14 pp. 29-39 "Physical barriers to drug delivery in tumors". V. Hird et al, Genes and Cancer, edited by Desmond Carney & Karol Sikora, pp. 183-189, "Immunotherapy with Monoclonal Antibodies". (1990). Michael E. Osband et al., Immunology Today, vol. 11, No. 6 1990, pp. 93-95, "Problems in the investigational study and clinical use of cancer immunotherapy". Tibtech Feb. 1993 vol. 11, pp. 42-44 "Therapeutic antibodies--the coming of age". Thomas A. Waldmann, Articles Jun. 21, 1991, pp. 1657-1662, "Monoclonal Antibodies in Diagnosis and Therapy". Douglas et al., Chemistry and Industry, 22:748-751, 1985. Finch, Chemistry and Industry, 22:752-756, 1985.

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