Monoclonal

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388.1
This subclass is indented under subclass 387.1.  Subject matter involving an antibody or fragment thereof produced by a clone of cells or cell line that is derived from a single antibody-producing cell, wherein said antibody is identical to all other antibodies produced by that clone of cells or cell line.
(1) Note. This subclass provides for antibodies and fragments thereof that are produced by any cloning technology that yields identical molecules, e.g., hybridoma technology, recombinant DNA technology, etc.
(2) Note. Monoclonal antibodies are sometimes termed monoclonal receptors.
(3) Note. This subclass includes monoclonal antibodies whose binding specificities are not disclosed and includes methods of purifying monoclonal antibodies, per se.

 
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Patent Number
Title
  Date
4427653 Method of making monoclonal antibodies Jan-24-1984
Methods featuring, in one aspect, a method of preparing an antigen or mixture of antigens substantially free of antigens specific to at least two monoclonal antibodies, said method involving contacting an antigen mixture with one or more previously-isolated monoclonal antibodies to form complexes between...     
4469630 Purification of monoclonal antibodies Sep-4-1984
A method of chromatographically separating monoclonal antibody type IgG from mouse ascites fluid utilizing a particular chromatographic packing of silica gel bearing bound polyethylenimine functions.
4560504 Carboxyl anchored immobilized antibodies Dec-24-1985
An immobilized antibody system can be made by reacting an aminated core support with an antibody in the presence of a condensing agent which promotes the formation of the amide linkage. The immobilized antibody system is highly resistant to leaching, may be made incompressible, sterilizable, and pyrogen-free....     
4604235 Purification of monoclonal antibodies Aug-5-1986
A method of chromatographically separating monoclonal antibody type IgM from mouse ascites fluid utilizing a particular chromatographic packing of silica gel bearing bound polyethylenimine functions.
4666697 Radioactive diagnostic agent May-19-1987
A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage...     
4722892 Monoclonal antibodies against metal chelates Feb-2-1988
Monoclonal Antibodies which are specific for a complex of a chelating agent and a metallic ion are described. The antibody has an association constant (K.sub.a) for the complex which is at least about ten times greater than the K.sub.a for the chelating agent alone or its complex with another metal.
4841024 Purification of antibodies Jun-20-1989
I(g)G3 antibody is purified by affinity chromatography and collection of released antibody at a pH of 9.0 to 9.6. The purification is effected in a column containing both an affinity matrix and a desalting matrix, with the column being equilibrated to a pH of from 9.0 to 9.6. I(g)G3 antibody may be stored...     
4841025 Antibody preparations Jun-20-1989
A monoclonal antibody preparation having a single binding activity, which activity is in respect of a cell surface antigen, comprises IgG antibody molecules in which only one of the two light chains will bind to said antigen, the proportion of such antibody molecules being enhanced relative to IgG antibody...     
4842998 Heterohybridoma screening method Jun-27-1989
Human-nonhuman heterohybridomas capable of expressing IgM type antibodies can be screened to select hybridomas expressing IgM antibodies comprising human J chain components. Method comprises contacting separate samples of IgM antibodies (or IgM J chain components) from a given cell line with anti-human...     
4849508 Pasteurization of immunoglobulin solutions Jul-18-1989
Pasteurization of immunoglobulin solutions to inactivate viruses without significantly altering the IgG molecules or their physiological activities is obtained with minimal aggregation in the absence of any stabilizer by heating this solution to mildly-elevated temperatures at low ionic strength and...     
4912202 Dihydropyridine receptor and antibodies thereto Mar-27-1990
Monoclonal antibodies capable of immunoprecipitating labeled dihydropyridine receptor material from digitonin-solubilized skeletal muscle triads are disclosed. Said antibodies recognize a 170,000 dalton protein subunit of the dihydropyridine receptor.
4935339 Delayed solid phase immunologic assay Jun-19-1990
A method for the determination of a substance present in a sample, which comprises: (a) contacting a sample containing a substance with: (i) a first immunological binding partner to the substance, wherein the first immunological binding partner is a monoclonal antibody bound to biotin or a biotin-binding...     
4939176 Viral inactivation process Jul-3-1990
Lipid-enveloped viruses present in purified biologically active protein products obtained from blood or cell culture systems can be inactivated by contacting the products with caprylic acid at a non-ionized concentration, pH, temperature and ionic environment sufficient to inactivate the viruses without...     
4952676 Monoclonal antibody-platinum co-ordination compound complex Aug-28-1990
A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilizes the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
4957735 Target-sensitive immunoliposomes- preparation and characterization Sep-18-1990
Novel target-sensitive immunoliposomes were prepared and characterized. In this invention, target specific binding of antibody-coated liposomes was sufficient to induce bilayer destabilization, resulting in a site-specific release of liposome contents. Unilamellar liposomes were prepared by using a small...     
5028540 Avian immunoglobulin-producing cell lines Jul-2-1991
The present invention involves a method for preparing antibody-producing chicken cell clones. This method comprises a series of steps including initially immunizing a first chicken with a desired antigen. A population of antibody-producing lymphocytes from bursa or spleen of the first chicken is separated....     
5028696 Ion exchange and separation method Jul-2-1991
A method of separating charged molecules having different numbers of charges thereon includes the step of passing the molecules to be separated through ion-exchange material such as an ion-exchange chromatograpy column in normal manner so that molecules to be separated bind to the ion-exchange material....     
5049502 Chicken-derived immunoglobulin-producing cell lines Sep-17-1991
The present invention involves a method for preparing antibody-producing chicken cell clones. This method comprises a series of steps including initially immunizing a first chicken with a desired antigen. A population of antibody-producing lymphocytes from bursa or spleen of the first chicken is separated....     
5077391 Purification of immunoglobulin M Dec-31-1991
Immunoglobulin M is purified by absorption upon an insoluble matrix material having chemically bound thereon the protein C1q. The matrix is washed and purified immunoglobulin M is then released from the matrix.
5084559 Protein A domain mutants Jan-28-1992
The subject invention concerns novel protein A or protein A-like molecules that can be coupled to other materials through a single, defined site on the protein A molecule. Specifically exemplified is Cysteinyl-rProtein A.TM.. The compounds of the invention, for example, Cysteinyl-rProtein A.TM., can...     
5089605 Immobilized immunoglobulin-binding proteins Feb-18-1992
The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support...     
5110913 Antibody purification method May-5-1992
Method of purifying a protein from a solution of substances comprising the steps of passing the solution through an ion exchange material at a pH which facilitates binding of the protein of interest, washing the bound protein at a different pH at which the bound protein does not elute but which the free...     
5156965 Catalytic antibodies Oct-20-1992
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formulation of a complex between the antibody and the reactant. The...     
5159064 Preparation of virus-free antibodies Oct-27-1992
Antibodies, including monoclonal antibodies (Mabs), can be made substantially free of infectious viruses by storing them in a liquid state at conditions of pH, temperature and time sufficient to inactive substantially all infectious viruses. Preferred inactivation methods involve use of a pH equal to...     
5179019 Therapeutic murine monoclonal antibody Jan-12-1993
The present invention relates to a monoclonal antibody which is broadly reactive with all normal human peripheral blood mononuclear cells and granulocyte, and to the hybridoma cell line which produces this monoclonal antibody. This monoclonal antibody is designated WM-65 and the hybridoma cell line is...     
5192694 Anti-PCI monoclonal antibody Mar-9-1993
A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal antibody as an immunoadsorbent. The human placenta-derived...     
5194254 Enhancement of antigen immunogenicity Mar-16-1993
A new method is described for eliciting IgG antibody response to proteins or synthetic peptides, particularly those that are weakly immunogenic, without the requirement for the use of adjuvants, thereby making it easier and safer to confer protection against pathogenic organisms. The antigen is coupled...     
5208021 Method of preparing diphtheria immunotoxins May-4-1993
A potent and specific immunotoxin is prepared by coupling an inactivated diphteria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the...     
5217869 Method to produce immunodiagnostic reagents Jun-8-1993
Screening methods to obtain suitable antibodies for use in immunoassays for analytes not ordinarily susceptible to detection by this means involves in vitro screening of panels of cells secreting a representative selection of antibodies. An application of this method also permits the preparation of specific...     
5231000 Antibodies to A4 amyloid peptide Jul-27-1993
Monoclonal antibodies to a 28-mer peptide present within A4-amyloid are described. These antibodies exhibit unexpected specificity for amyloid plaque structures previously unrecognized in Alzheimer's disease brains. These monoclonal antibodies are useful as reagents for use in assays and imaging of A4-amyloid...     
5231025 Anti-platelet monoclonal antibody Jul-27-1993
A unique anti-platelet monoclonal antibody which binds to human platelet glycoprotein IV, and various utilities of the monoclonal antibody are described.
5231170 Antibodies to dense microspheres Jul-27-1993
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds...     
5237054 Stabilized aqueous composition containing antibodies Aug-17-1993
A stabilized aqueous antibody composition comprising dextran as a stabilizer in an amount sufficient to prevent deactivation of the monoclonal antibodies at a temperature in the range of 4.degree. to 40.degree. C.
5258299 Avian immunoglobulin-producing cell lines Nov-2-1993
The present invention relates to a method of preparing efficiently producing antibody avian cell clones. The method generally involves infecting a B-lymphocyte population with a v-rel gene using transfe The government may have certain rights in the invention pursuant to grant No. CA 41450 from the National...     
5260203 Single polypeptide chain binding molecules Nov-9-1993
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant...     
5275935 Amebic glycoconjugate and monoclonal antibody Jan-4-1994
An amebic glycoconjugate is disclosed that is recognized by an Entamoeba histolytica specific monoclonal antibody The glycoconjugate is isolated from the lysates of E. histolytica trophozoites, it is phosphorylated, lipid-containing, glycosylated, migrates as a polydisperse band on SDS-PAGE between about...     
5286851 Monoclonal antibodies to anthracyclines Feb-15-1994
Monoclonal antibodies able to selectively bind to doxorubicin and its analogues and derivatives are disclosed.
5331093 Anti-focosylceramide monoclonal antibody Jul-19-1994
The invention relates to a monoclonal antibody PC47H specifically recognizing fucosylceramide derived from a ceramide-mono-glycoside fraction of neutral glycolipid extracted and purified from human cancer tissues and having properties such as belonging to IgM and showing reactivity to neither of normal...     
5470957 Immunoinhibitors of factor XIII Nov-28-1995
Novel immunoinhibitors are capable of inhibiting thrombin-activated function of Factor XIII by binding to Factor XIII at a site other than the thrombin-cleavage site of Factor XIII.
5486472 Monoclonal antibodies to PACAP Jan-23-1996
Disclosed are a monoclonal antibody having affinity for PACAP, a partial peptide thereof, a precursor thereof or VIP; a hybridoma cell which produces the above monoclonal antibody; and an immunoassay for assaying PACAP by a competitive method or a sandwich method using the above antibody, whereby PACAP...     
5495002 Tumor associated monoclonal antibody 123AV16 Feb-27-1996
This invention relates to transformed B-cell lines derived from peripheral blood B-cells of cancer patients actively immunized with autologous tumor antigen and the monoclonal antibodies they produce. These monoclonal antibodies can be used in both diagnostic procedures and therapy for human cancers.
5519120 Urokinase-type plasminogen activator receptor antibodies May-21-1996
A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR...     
5520914 Antibodies to angiogenin: immunotherapeutic agents May-28-1996
This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab or F(ab').sub.2 fragments thereof so as to inhibit angiogenic activity. In addition, this invention relates...     
5523229 Antibodies specific for oncofetal fibronectin Jun-4-1996
Immunologic binding partners which specifically bind to oncofetal fibronectin but not normal adult fibronectin or blood plasma fibronectin and methods of diagnosing and treating oncogenesis and reproductive abnormalities employing the same.
5558865 HIV immunotherapeutics Sep-24-1996
The present invention provides monoclonal antibodies that are specifically immunoreactive with an HIV-1 gp120 protein or its precursor gp160 protein comprising the amino acid sequence set out in SEQ ID NO: 1, G-P-G-R, and characterized by their ability to neutralize, in vitro, the infection of H9 cells...     
5559000 Encoded reaction cassette Sep-24-1996
A reaction cassette has been designed for the highly sensitive detection of the making and breaking of chemical bonds. The system may be employed as a companion device to be used in the search for antibody and other novel catalysts. The cassette also has important clinical applications in the design...     
5565337 Hybridoma-producing NSO myeloma cell line Oct-15-1996
This invention relates to an NSO myeloma cell line which has increased fusion frequency, and to a method of producing said cell line. The NSO cell line of the invention, when fused with B cells, produces monoclonal antibody-secreting hybridoma which has increased resistance to death. In addition, the...     
5614195 Coccidiosis poultry vaccine Mar-25-1997
This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation...     
5622835 WT1 monoclonal antibodies Apr-22-1997
Three unique monoclonal antibodies, each having an epitope located in amino acids 1-181 of the WT1 tumor protein, and the hybridomas which secrete them have been constructed. These monoclonal antibodies are useful in the detection, monitoring, and diagnosis of malignancies characterized by inappropriate...     
5629197 Monoclonal anti-human breast cancer antibodies May-13-1997
Murine monoclonal antibodies are prepared and characterized which bind selectively to high molecular weight mucins by immunoprecipitation test and are IgGs or IgMs. Immunotoxins comprising the monoclonal antibody and cytotoxic moiety were produced.
5629415 DNA encoding canine immunoglobulin E May-13-1997
The present invention relates to DNA molecules encoding a canine IgE and species-specific regions of the canine IgE constant region. The invention comprises the DNA molecules, proteins encoded by the DNA molecules, antibodies to the proteins, cells transformed by the DNA molecules, assays employing the...     
5639621 Monoclonal antibodies against tumor-associated antigens Jun-17-1997
The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation...     
5641669 Platelet-activating factor acetylhydrolase Jun-24-1997
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful...     
5641866 Bcl-2-associated proteins Jun-24-1997
The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically...     
5652109 Antibodies to .alpha.v.beta.3 integrin Jul-29-1997
The invention relates to monoclonal antibodies to the .alpha.v.beta.3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on .alpha.v.beta.3...     
5652110 Antibodies to .alpha.v.beta.3 integrin Jul-29-1997
The invention relates to monoclonal antibodies to the .alpha.v.beta.3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on .alpha.v.beta.3...     
5660827 Antibodies that bind to endoglin Aug-26-1997
Disclosed are antibodies that specifically bind to endoglin. Conjugates of the antibodies linked to diagnostic or therapeutic agents are also provided. Methods of using the antibodies and conjugates are also disclosed, including methods of targeting the vasculature of solid tumors through recognition...     
5665356 Human anti-Rh (D) monoclonal antibodies Sep-9-1997
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG1 proteins; (c) having kappa light chains; (d) being Glm(3) or Glm(1,17) allotype; (e) binding...     
5665595 Immunoglobulins against insect tissue Sep-9-1997
The present invention provides a composition and method of protecting plants otherwise susceptible to infestation by insects of the orders Lepidoptera and Coleoptera.
5686070 Methods for treating bacterial pneumonia Nov-11-1997
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
5688651 Prevention of protein aggregation Nov-18-1997
A method of selecting anti-aggregation molecules with chaperone-like activity that have characteristics including binding to a native target molecule epitope with a high binding constant and are non-inhibitory to the biological activity of the target molecule. The method molecules denaturating a target...     
5688927 Macrophage derived chemokine Nov-18-1997
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C--C chemokine designated MDC. Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein.
5707622 Methods for treating ulcerative colitis Jan-13-1998
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
5707801 Manual in situ hybridization assay Jan-13-1998
A rapid, sensitive in situ hybridization assay is provided which will detect as few as 1-5 copies of target biopolymer per cell and may be accomplished in 2-4 hours. There is provided a quantitative assay which may be used to diagnose and monitor treatment of diseases.
5708145 Immunglobulins reactive with protegrins Jan-13-1998
Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection...     
5712372 Human thyroid hormone receptor Jan-27-1998
The present invention relates generally to DNA sequences encoding human thyroid hormone receptor proteins and more particularly to DNA sequences encoding human thyroid hormone receptor protein designated hTR.alpha.1, to the polypeptide products of recombinant expression of these DNA sequences, to peptides...     
5717071 Cross-protective human monoclonal antibody compositions Feb-10-1998
Cell lines have been produced that secrete human monoclonal antibodies capable of binding to molecules of different bacterial species. These antibodies have been found to be protective against lethal challenges of various bacterial genera. Pharmaceutical compositions containing these antibodies, which...     
5719268 Endothelial cell adhesion molecules Feb-17-1998
Methods and compositions are provided for the modulation of monocyte binding to endothelial cells, particularly during inflammatory episodes. Compositions are provided which bind to one or both of the monocyte surface membrane protein or the endothelial surface membrane protein which are complementary...     
5730977 Anti-VEGF human monoclonal antibody Mar-24-1998
The present invention provides an anti-VEGF human monoclonal antibody capable of binding to human VEGF to neutralize its activity, a cell strain producing said human monoclonal antibody, and a vascularization inhibitor containing said human monoclonal antibody. Hybridoma strains VA01 and BL2 producing...     
5744584 Antithrombosis agents Apr-28-1998
Platelet antiadhesives (PAA) which are useful as antithrombotics are obtainable from snake venoms which have been identified using an assay which measures the ability of the venom to inhibit ristocetin- or botrocetin-induced agglutination of platelets in the presence of von Willebrand Factor. The antiadhesives...     
5747037 Anti-GP39 antibodies May-5-1998
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced...     
5753450 Bone resorption assay May-19-1998
Compositions and methods are provided which are useful in determining the levels of the C-telopeptide of human Type I collagen. The levels of the C-telopeptide are used as a marker of collagen degradation in an individual, and thus serve as a sensitive and specific indicator of bone resorption. Assays...     
5756682 Assay for cardiac troponin I May-26-1998
A method for detection of cardiac troponin I is described. The method is a sandwich assay employing an antibody specific for cardiac troponin I as one binding partner and troponin C as the other binding partner for cardiac troponin I.
5756683 Immunological detection method May-26-1998
The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards herbicides from the group of the sulfonylureas, especially towards sulfonylurea herbicides of formula (A) ##STR1## wherein X is a mono- or di-substituted 6-membered heterocycle...     
5759808 Immunoglobulins devoid of light chains Jun-2-1998
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.
5766590 Therapeutic methods and pharmaceutical compositions Jun-16-1998
The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularly, the invention is directed to a monoclonal antibody,...     
5767248 Apolipoprotein E isoform-specific monoclonal antibodies Jun-16-1998
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted...     
5770198 Platelet-specific chimeric 7E3 immunoglobulin Jun-23-1998
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred immunoglobulins are specific for glycoprotein IIb/IIIa receptor in its complexed form; they block ligand...     
5770208 Staphylococcus aureus B-linked hexosamine antigen Jun-23-1998
A negatively-charged S. aureus antigen contains .beta.-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant strains of S. aureus that are not Type 5 or Type 8 strains. The antigen can be used in combination with S....     
5773293 Anti-ICAM-4 antibodies and hybridomas Jun-30-1998
DNA sequences encoding a novel intercellular adhesion molecule polypeptide (designated "ICAM-4") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibody molecules that bind to ICAM-4, and uses thereof, are also disclosed.
5776775 Anti-LAM 1-3 antibody and hybridoma Jul-7-1998
A hybridoma cell line produced by the fusion of NS-1 myeloma cells with spleen cells obtained from mice immunized with Leukocyte Adhesion Molecule-1 (LAM-1) cDNA transfected cells. The cell line produces a monoclonal antibody reactive with human, monkey, cow, rabbit, sheep, dog, cat, pig and goat LAM-1....     
5780595 Platelet aggregation inhibitors Jul-14-1998
Peptides useful in inhibiting platelet aggregation are disclosed. These peptides contain the binding sequence Har-G-D and are disulfide-bridged cyclic compounds.
5783383 Method of detecting cytomegalovirus (CMV) Jul-21-1998
The present invention provides methods and compositions relating to cytomegalovirus (CMV) latent transcripts, latency-associated polypeptides and antibodies directed against such polypeptide. The polypeptides are encoded by CMV DNA sequences and are produced specifically during latent infection. Also...     
5789178 Neutrophil inhibitors Aug-4-1998
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein...     
5792838 Method for stabilizing immunoglobulin compositions Aug-11-1998
The invention relates to a stabilised immunoglobulin composition comprising at least one immunoglobulin together with a stabilising amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example a recombinant CDR-grafted antibody against the CDw52...     
5795961 Recombinant human anti-Lewis b antibodies Aug-18-1998
The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the...     
5801227 Antibodies to CD40 Sep-1-1998
The present invention provides monoclonal antibodies and binding proteins which specifically bind to CD40 and are capable of blocking binding of CD40 to CD40 ligand.
5808009 Method of affinity purifying antibodies Sep-15-1998
The present invention relates to a method of affinity purifying antibodies consisting of the following steps: A) homogenizing Helminth parasite worms forming a mixture; B) incubating the mixture of adult Helminth parasite worm homogenate with pre-swelled CNBr-activated Sepharose 4B in coupling buffer;...     
5811247 Monoclonal antibodies to nucleolar protein Sep-22-1998
The invention relates to a hybridoma cell line which produces a monoclonal antibody which cross reacts with both yeast and human fibrillarin. Diagnostic kits are also described. These are useful in diagnosing diseases such as scleroderma.
5817513 Anti ganglioside monoclonal antibodies Oct-6-1998
The present invention relates to immunotherapy strategies for the treatment of malignancies. The present immunotherapy strategies have gangliosides as a target. Gangliosides are glycosphingolipids which are present on normal cells and on malignant cells. On malignant cells they are more abundant and...     
5821123 Modified antibody variable domains Oct-13-1998
Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable...     
5821224 Antimicrobial peptides from bovine neutrophils Oct-13-1998
The present invention provides a new family of cysteine-rich antimicrobial peptides isolated from bovine neutrophils herein named beta defensins. Thirteen structurally homologous peptides were purified to homogeneity from a granule-rich cytoplasmic fraction of purified blood neutrophils. These antimicrobial...     
5821341 Antibodies to sICAM-1 Oct-13-1998
The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1, and antibodies thereto. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1...     
5827668 Immunodiagnostic assay for rheumatoid arthritis Oct-27-1998
The assay of rheumatoid arthritis by reference to IgA-.alpha..sub.1 antitrypsin complex present in analytes is facilitated by certain novel antibody reagents. These are ligands comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and .alpha..sub.1 -antitrypsin,...     
5830742 TNF-.alpha. converting enzyme Nov-3-1998
A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof,...     
5831029 Human .beta.2 integrin .alpha. subunit Nov-3-1998
DNA encoding a novel human .beta..sub.2 integrin .alpha. subunit polypeptide, designated .alpha..sub.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which include extracellular .alpha..sub.d protein fragments, .alpha..sub.d...     
5831032 Interleukin-8 anti-peptide antibodies Nov-3-1998
Polypeptide analogs, antibodies, diagnostic and therapeutic compositions as well as methods for detecting the presence of IL-8 and preventing the inflammatory response in patients are described.
5843708 Chimeric antibodies Dec-1-1998
The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies,...     
5852167 Totally synthetic affinity reagents Dec-22-1998
A novel method for producing novel and/or improved heterofunctional binding fusion proteins termed Totally Synthetic Affinity Reagents (TSARs) is disclosed. TSARs are concatenated heterofunctional proteins, polypeptides or peptides comprising at least two functional regions: a binding domain with affinity...     
5852175 P-selectin glycoprotein ligand blocking antibodies Dec-22-1998
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of ›.sup.3 H!glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and...     
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